Bcs Class Iii
The results with BCS class III drugs demonstrated bioequivalence using the prolonged release rate, T(85%) = 45 or 60 min, indicating that the dissolution standard for bioequivalence is dependent on the intestinal membrane permeability and permeability profile throughout the gastrointestinal tract.
Antiarrhythmic Drugs
Frank J. Dowd, in Pharmacology and Therapeutics for Dentistry (Seventh Edition), 2017
Bcs Class 3 Drugs List
Ibutilide and Dofetilide
Bcs Class Iii Exam
Ibutilide is classified as a class III drug because it delays repolarization. It blocks Kr channels and causes the opening of Ca2+ channels, which promote Na+ influx through slow channels, extending phase 2 of the action potential. The drug is administered intravenously for atrial fibrillation and atrial flutter. It can be used to convert these arrhythmias, especially of recent onset, to normal sinus rhythm. Hypotension and arrhythmias are adverse effects.
Dofetilide is considered a “pure” class III drug, blocking the Kr channel selectively. It is used for acute conversion of atrial fibrillation and atrial flutter and for short-term maintenance of normal sinus rhythm. Dofetilide is available for intravenous and oral use. The structures for ibutilide and dofetilide are shown in Figure 19-9.